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이대은 ( Lee Dae-Eun ) - Pusan National University College of Nursing
이해정 ( Lee Hae-Jung ) -
신윤영 ( Shin Yoon-Young ) -
박가은 ( Park Ga-Eun ) -
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Abstract
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Purpose Evidence on non-pharmacological interventions for adolescents with type 1 diabetes is unclear. This review aimed to evaluate the effectiveness of non-pharmacological intervention in adolescents with type 1 diabetes.
Methods We conducted a search on databases from November 11 to 19, 2022, for randomized controlled trials for the effects of non-pharmacological intervention in adolescents with type 1 diabetes. To identify recent research trends, we included studies published from 2017 to November 2022. The risk of bias was assessed using the Cochrane risk-of-bias tool 2.0. To estimate the effect size, a meta-analysis was performed using RevMan 5.4 program and R Studio.
Results A total of 45 studies were included in the systematic review. Among those, 30 studies were included in the meta-analysis. Non-pharmacological interventions were significantly effective in improving Glycated hemoglobin (HbA1c) (standardized mean difference [SMD] = ?0.26, 95% confidence interval [CI]: ?0.42, ?0.09), quality of life (SMD = 0.44, 95% CI: 0.13 to 0.76), and anxiety (SMD = ?0.91, 95% CI: ?1.26, ?0.56). Subgroup analysis showed that duration of intervention was not a covariate related to HbA1c levels.
Conclusions Non-pharmacological interventions have shown effectiveness in improving the HbA1c, quality of life, and anxiety in adolescents with type 1 diabetes. Future studies with more rigorous methodology are needed to confirm and strengthen the validity of these findings. Additionally, attention to changes in the lipid profile and self-care motivation among adolescents with type 1 diabetes is warranted.
Trial registration number Prospective Register of Systematic Reviews (CRD42022382190).
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KeyWords
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adolescent, diabetes mellitus, meta-analysis, randomized controlled trial, type 1
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원문 및 링크아웃 정보
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등재저널 정보
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